Yi Tang

Our laboratory employs a multidisciplinary approach to investigate Alzheimer’s Disease (AD) and related cognitive impairments by integrating systems biology, neuroimaging, machine learning, genetic analysis, and non-pharmacological interventions.

International Academic Positions:

· Program Chair, Alzheimer's Association Non-Pharmacological Intervention PIA, 2016.12 - 2019.8

· Review Editor, Alzheimer’s & Dementia, 2023.1 - Present

· Senior Associate Editor, Alzheimer’s & Dementia, 2014.10 - 2022.12

· Senior Editor, Journal of Alzheimer’s Disease, 2021.01 - Present

Domestic Academic Positions:

· Leader, Expert Group of Cognitive Impairment Disease Specialized Capacity Construction Project, National Health Commission of China, 2021.9 - Present

· Deputy Director, Youth Committee of Neurology Branch, Chinese Medical Association, 2017.4 - Present

· Member, Dementia and Cognitive Impairment Group, Neurology Branch, Chinese Medical Association, 2020.9 - Present

· Vice President, Geriatrics Branch of Chinese Gerontology and Geriatrics Society, 2024.8 - Present

· Deputy Leader, Brain and Spinal Cord Group, Neurology Physician Branch, Chinese Medical Doctor Association, 2021.7 - Present

· Leader, Dementia and Cognitive Impairment Group, Neurology Branch, Beijing Medical Association, 2017.3 - Present

· Member, Anti-Aging and Alzheimer's Disease Professional Committee, Chinese Pharmacological Society, 2017.6 - Present

· Editorial Board Member, Chinese Medical Journal, 2023.11 - Present

· Editorial Board Member, Chinese Journal of Neurology, 2021.1 - Present

· Editorial Board Member, Journal of Stroke and Neurological Diseases, 2019.5 - Present

Selected Talent Programs:

· Beijing University Outstanding Young Scientist Program, 2024.4

· Beijing Municipal High-Level Scientific Research and Innovation Team, 2023.2

· Young Beijing Scholar, 2022.9

· Beijing "Peak" Talent Program, 2022.5

· Cheung Kong Scholars Program, 2022.1

· Beijing Outstanding Youth Science Fund, 2019.11

· Beijing High-Level Innovation and Entrepreneurship Talent Leader, 2017.2

· Beijing "Hundred, Thousand, Ten Thousand" Talents Project, 2016.6

· Beijing High-Level Innovation and Entrepreneurship Talent Support Program, 2015.1

· Beijing Outstanding Talent Youth Project, 2015.1

· Beijing Health System High-Level Health Technology Talent, 2014.12

· Beijing Technology Star, 2010.12

Awards:

· First Prize, China Medical Science and Technology Award, First Completer, 2023.12

· First Beijing Advanced Science and Technology Worker, 2023.7

· First China Top Ten Outstanding Young Neurologists Award, 2016.8

· First Prize, Beijing Science and Technology Progress Award, Sixth Completer, 2021.9

· Second Prize, China Medical Science and Technology Award, Sixth Completer, 2021.3

1. Wang Z, Wang C, Wei T, Mi Y, Zhou S, Liu X, Jia J, Li L, Zhao G, Tang Y*. Impaired temporal coding associated with central auditory dysfunction and cognitive impairment in Alzheimer's disease. Sci Bull (Beijing). 2024 Oct 16:S2095-9273(24)00751-5. doi: 10.1016/j.scib.2024.10.012.

2. Shen H, Yu Y, Wang J, Nie Y, Tang Y*, Qu M*. Plasma lipidomic signatures of dementia with Lewy bodies revealed by machine learning, and compared to alzheimer's disease. Alzheimers Res Ther. 2024 Oct 15;16(1):226. doi: 10.1186/s13195-024-01585-7.

3. Yang K, Yang X, Yin P, Zhou M, Tang Y*. Temporal trend and attributable risk factors of Alzheimer's disease and other dementias burden in China: Findings from the Global Burden of Disease Study 2021. Alzheimers Dement. 2024 Sep 23. doi: 10.1002/alz.14254.

4. Wang T, Yan S, Shan Y, Xing Y, Bi S, Chen Z, Xi H, Xue H, Qi Z, Tang Y*, Lu J*. Altered Neuronal Activity Patterns of the Prefrontal Cortex in Alzheimer's Disease After Transcranial Alternating Current Stimulation: A Resting-State fMRI Study. J Alzheimers Dis. 2024 Sep 12. doi: 10.3233/JAD-240400.

5. Tang Y*, Xing Y, Sun L, Wang Z, Wang C, Yang K, Zhu W, Shi X, Xie B, Yin Y, Mi Y, Wei T, Tong R, Qiao Y, Yan S, Wei P, Yang Y, Shan Y, Zhang X, Jia J, Teipel SJ, Howard R, Lu J, Li C, Zhao G. TRanscranial AlterNating current stimulation FOR patients with mild Alzheimer's Disease (TRANSFORM-AD): a randomized controlled clinical trial. Alzheimers Res Ther. 2024 Sep 12;16(1):203. doi: 10.1186/s13195-024-01570-0.

6. Liu L, Wang H, Xing Y, Zhang Z, Zhang Q, Dong M, Ma Z, Cai L, Wang X, Tang Y*. Dose-response relationship between computerized cognitive training and cognitive improvement. NPJ Digit Med. 2024 Aug 15;7(1):214. doi: 10.1038/s41746-024-01210-

7. Liu Y, Wang Z, Wei T, Zhou S, Yin Y, Mi Y, Liu X, Tang Y*. Alterations of Audiovisual Integration in Alzheimer's Disease. Neurosci Bull. 2023 Dec;39(12):1859-1872. doi: 10.1007/s12264-023-01125-7.

8. Liu LY, Xing Y, Zhang ZH, Zhang QG, Dong M, Wang H, Cai L, Wang X, Tang Y*. Validation of a Computerized Cognitive Training Tool to Assess Cognitive Impairment and Enable Differentiation Between Mild Cognitive Impairment and Dementia. J Alzheimers Dis. 2023;96(1):93-101. doi: 10.3233/JAD-230416.

9. Yang H, Qin Q, Wang M, Yin Y, Li R, Tang Y*. Crosstalk between peripheral immunity and central nervous system in Alzheimer's disease. Cell Immunol. 2023 Sep-Oct;391-392:104743. doi: 10.1016/j.cellimm.2023.104743.

10. Teipel S, Tang Y, Boccardi M. Predicting cognitive decline in older people by structural and molecular imaging. Curr Opin Neurol. 2023 Aug 1;36(4):253-263. doi: 10.1097/WCO.0000000000001172.

11. Qin Q, Qu J, Yin Y, Liang Y, Wang Y, Xie B, Liu Q, Wang X, Xia X, Wang M, Zhang X, Jia J, Xing Y*, Li C*, Tang Y*. Unsupervised machine learning model to predict cognitive impairment in subcortical ischemic vascular disease. Alzheimers Dement. 2023 Feb 14. doi: 10.1002/alz.12971.

12. Liu PP, Dai SK, Mi TW, Tang GB, Wang Z, Wang H, Du HZ, Tang Y*, Teng Z*, Liu CM*. Acetate supplementation restores cognitive deficits caused by ARID1A haploinsufficiency in excitatory neurons. EMBO Mol Med. 2022;e15795. doi:10.15252/emmm.202215795.

13. Lutz MW, Khachaturian AS, Zetterberg H, Blennow K, Willette AA, Mielke MM, Hayden KM, Dodge HH, Tang Y, Greenberg BD, Kukull WA, Khachaturian ZS. Biomarkers of Alzheimer syndrome and related dementias: A&D author's guide. Alzheimers Dement. 2022 Sep;18(9):1595-1601. doi: 10.1002/alz.12772.

14. Zhang SF, Dai SK, Du HZ, Wang H, Li XG, Tang Y*, Liu CM*. The epigenetic state of EED-Gli3-Gli1 regulatory axis controls embryonic cortical neurogenesis. Stem Cell Reports. 2022 Sep 13;17(9):2064-2080. doi: 10.1016/j.stemcr.2022.07.004.

15. Li RY, Qin Q, Yang HC, Wang YY, Mi YX, Yin YS, Wang M, Yu CJ, Tang Y*. TREM2 in the pathogenesis of AD: a lipid metabolism regulator and potential metabolic therapeutic target. Mol Neurodegener. 2022 Jun 3;17(1):40. doi: 10.1186/s13024-022-00542-y.

16. Wang YY, Deng YS, Dai SK, Mi TW, Li RY, Liu PP, Liu C, HeBD, He XC, Du HZ, Yang HC, Tang Y*, Liu CM*, Teng ZQ*. Loss of microglial EED impairs synapse density, learning and memory. Mol Psychiatry. 2022 Jul; 27(7):2999-3009. doi: 10.1038/s41380-022-01576-w.

17. Mi Y, Qin Q, Xing Y, Tang Y*. Capgras Syndrome as the Core Manifestation of Early-Onset Alzheimer's Disease. J Alzheimers Dis. 2022 Mar 2. doi: 10.3233/JAD-215565.

18. Teipel S, Gustafson D, Ossenkoppele R, Hansson O, Babiloni C, Wagner M, Riedel-Heller S, Kilimann I, Tang Y. Alzheimer's disease - standard of diagnosis, treatment, care, and prevention. J Nucl Med. 2022 Feb 10:jnumed.121.262239. doi: 10.2967/jnumed.121.262239.

19. Xing Y, Yang J, Zhou A, Wang F, Tang Y*, Jia J*. Altered brain activity mediates the relationship between white matter hyperintensity severity and cognition in older adults. Brain Imaging Behav. 2021 Oct 20. doi: 10.1007/s11682-021-00564-y.

20. Wang C#, Wang Z#, Xie B, Shi X, Yang P, Liu L, Qu T, Qin Q, Xing Y, Zhu W, Teipel SJ, Jia J, Zhao G*, Li L*, Tang Y*. Binaural processing deficit and cognitive impairment in Alzheimer’s disease. Alzheimers Dement. 2022;18(6):1085-1099. doi:10.1002/alz.12464DOI: 10.1002/alz.12464.

21. Tang Y*, Xing Y, Cui L, Wu C, Wen X, Song H, Wu L, Chang H, Song J, Wang Y*, Zhao G*. Neurology practice during the COVID-19 outbreak and post-pandemic era: experiences and challenges. Eur J Neurol. 2020;27(12):e81-e83. doi:10.1111/ene.14445

22. Xing Y, Zhu Z, Du Y, Zhang J, Qu Q, Sun L, Li Y, Guo Y, Peng G, Liu Y, Yu Y, Qiao Y, Xie B, Shi X, Lu J, Jia J, Tang Y*. The Efficacy of Cognitive training in patients with Amnestic mild cognitive impairment (COG-REAGENT): Protocol for a Multi-Center Randomized Controlled Trial. J Alzheimers Dis. 2020;75(3):779-787.

23. Xing Y, Wei P, Wang C, Shan Y, Yu Y, Qiao Y, Xie B, Shi X, Zhu Z, Lu J, Zhao G, Jia J, Tang Y*. TRanscranial AlterNating current Stimulation FOR patients with Mild Alzheimer's Disease (TRANSFORM-AD study): Protocol for a randomized controlled clinical trial. Alzheimers Dement (N Y). 2020;6(1):e12005.

24. Tang Y#*, Xing Y#, Zhu Z#, He Y, Li F, Yang J, Liu Q, Li F, Teipel SJ, Zhao G*, Jia J*. The effects of 7-week cognitive training in patients with vascular cognitive impairment, no dementia (the Cog-VACCINE study): A randomized controlled trial. Alzheimers Dement. 2019;15(5):605-614.

25. Tang Y*, Lutz MW, Xing Y. A systems-based model of Alzheimer's disease. Alzheimers Dement. 2019;15(1):168-171.